WoundClot Hemostatic Gauze comprises of complete new hierarchy of material engineering from its molecular level, through optimization of its physical properties, interaction with blood and maximization of its clotting promotion capabilities. The synergy in all these aspects enables managing severe traumatic hemorrhage with high efficiency.
WOUNDCLOT MODE OF OPERATION
Upon the placement of WoundClot dressing on the bleeding site, the product’s unique gel utilizes the hydration forces between the mucosal layer and itself which results in a strong physical attraction that leads to the adherence of the product to the tissue. The stronger the bleeding pressures in the wound, the stronger the attraction.
For this to happen, the type of gel the product transforms into has to be precisely designed to be relatively slow forming with a vast ability to absorb bleeding without breaking down. This ability to absorb and maintain a stable membrane allows for the pooling of active coagulation factors in significant quantities to be sequestered in the membrane. The membrane flexibility on the molecular gel structure allows a hemo-dynamic environment in which rapid coagulation cascades are created given the large amount of coagulation factors present due to absorption capabilities.
The coagulation factors attach to the surface tissue and the membrane with the presence of a patented molecular group incorporated into the product. The coagulation process is initiated many times faster and stronger than at the surface of the wound by enhancing the presence of platelets, multiple coagulation factors, and amino acids. This dramatically reduces the flow of blood from the wound.
In turn, this process also increases the adherence of the membrane to the tissue making sure it is stable on the wound site.
Once bleeding has stopped and the coagulation cascade is formed, the capillary and hydration physical forces are reduced, allowing for the easy removal of WoundClot, if desired, as one piece without disrupting the clot already formed.
WoundClot was developed based on the understanding how the basic molecular and macrostructure of the material can affect the physical properties.
One of the biggest challenges in dealing with severe bleeding is the ability to control excessive bleeding while maintaining gel stability throughout its working operation time.
WoundClot is made by non-oxidative chemical reaction using cellulose as a substrate to build upon advance functional groups. Those functional molecular groups (FMG) were specifically designed to provide the material special physical and performance properties. They increase the blood affinity into the product while enhancing the inter-molecular forces between the polymeric chains. These additional interactions inhibit the rapid dissociation when expose to aqueous environment and preserve stable gel state for extended time.
The liquid uptake capabilities of WoundClot is over 2500 times its own weight. In case of need, when exposed to blood, the formed 3D matrix entraps platelets and coagulants in a hemodynamic environment. This allows the increasing of the concentration of blood ingredients at the wound vicinity while retaining their mobility and activity to form a biological clot. Moreover, those FMGs were designed to have a strong impact on the natural biological clotting process.
WoundClot initially forms a mechanical plug by adhering to the cavity slowing down the blood flow, then massive absorption of platelets directly on the cavity, form to speed the formation of a plug. The high levels of absorption cause this process to intensify many folds the natural amount of platelets in the plug.
Once the platelets interact with WoundClot, the FMG promotes the transformation of the platelets into their active state, which initiates the intrinsic clotting path. WoundClot affects the coagulation process by influencing plasma, turning Hageman factor (factor XII) from inactive to active (XIIa), turning plasma thromboplastin antecedent (factor XI) to active much longer and stronger then other common hemostats. The formed biological clot within the product after WoundClot application can be clearly seen unlike other common products in the market.